High-frequency oscillations in Parkinson's disease: spatial distribution and clinical relevance.
Identifieur interne : 000559 ( Main/Exploration ); précédent : 000558; suivant : 000560High-frequency oscillations in Parkinson's disease: spatial distribution and clinical relevance.
Auteurs : Jing Wang [République populaire de Chine] ; Jan Hirschmann ; Saskia Elben ; Christian J. Hartmann ; Jan Vesper ; Lars Wojtecki ; Alfons SchnitzlerSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- Aged, Brain Mapping, Brain Waves (physiology), Deep Brain Stimulation, Electrodes, Implanted, Electroencephalography, Female, Humans, Intraoperative Period, Male, Middle Aged, Parkinson Disease (pathology), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Severity of Illness Index, Spectrum Analysis, Subthalamic Nucleus (physiology).
- MESH :
- pathology : Parkinson Disease.
- physiology : Brain Waves, Subthalamic Nucleus.
- physiopathology : Parkinson Disease.
- therapy : Parkinson Disease.
- Aged, Brain Mapping, Deep Brain Stimulation, Electrodes, Implanted, Electroencephalography, Female, Humans, Intraoperative Period, Male, Middle Aged, Severity of Illness Index, Spectrum Analysis.
Abstract
The pathophysiology of Parkinson's disease (PD) has been related to excessive beta band oscillations in the basal ganglia. Recent recordings from the subthalamic nucleus of PD patients showed that beta oscillations show strong cross-frequency coupling with high-frequency oscillations (>200 Hz). However, little is known about the characteristics and functional properties of these oscillations. We studied the spatial distribution of high-frequency oscillations and their relation to PD motor symptoms. We included 10 PD patients in medication OFF who underwent implantation of deep brain stimulation (DBS) electrodes. Intraoperative five-channel microelectrode recordings were performed at 9 to 10 recording sites within the subthalamic nucleus and its immediate surroundings. We found a focal spatial distribution of high-frequency oscillations with highest power 2 mm below the dorsolateral border of the subthalamic nucleus. Within the subthalamic nucleus, power peaked slightly anterior to the DBS target site. In addition, contralateral akinesia/rigidity scores were negatively correlated with high-frequency oscillation power. Our results demonstrate a focal origin of high-frequency oscillations within the subthalamic nucleus and provide further evidence for their functional association with motor state.
DOI: 10.1002/mds.25962
PubMed: 25041924
Affiliations:
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Le document en format XML
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China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany; State Key Lab of Cognitive Neuroscience and Learning, Beijing Normal University</wicri:regionArea><wicri:noRegion>Beijing Normal University</wicri:noRegion></affiliation></author><author><name sortKey="Hirschmann, Jan" sort="Hirschmann, Jan" uniqKey="Hirschmann J" first="Jan" last="Hirschmann">Jan Hirschmann</name></author><author><name sortKey="Elben, Saskia" sort="Elben, Saskia" uniqKey="Elben S" first="Saskia" last="Elben">Saskia Elben</name></author><author><name sortKey="Hartmann, Christian J" sort="Hartmann, Christian J" uniqKey="Hartmann C" first="Christian J" last="Hartmann">Christian J. Hartmann</name></author><author><name sortKey="Vesper, Jan" sort="Vesper, Jan" uniqKey="Vesper J" first="Jan" last="Vesper">Jan Vesper</name></author><author><name sortKey="Wojtecki, Lars" sort="Wojtecki, Lars" uniqKey="Wojtecki L" first="Lars" last="Wojtecki">Lars Wojtecki</name></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25041924</idno><idno type="pmid">25041924</idno><idno type="doi">10.1002/mds.25962</idno><idno type="wicri:Area/PubMed/Corpus">000454</idno><idno type="wicri:Area/PubMed/Curation">000454</idno><idno type="wicri:Area/PubMed/Checkpoint">000569</idno><idno type="wicri:Area/Ncbi/Merge">004049</idno><idno type="wicri:Area/Ncbi/Curation">004049</idno><idno type="wicri:Area/Ncbi/Checkpoint">004049</idno><idno type="wicri:Area/Main/Merge">000559</idno><idno type="wicri:Area/Main/Curation">000559</idno><idno type="wicri:Area/Main/Exploration">000559</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">High-frequency oscillations in Parkinson's disease: spatial distribution and clinical relevance.</title><author><name sortKey="Wang, Jing" sort="Wang, Jing" uniqKey="Wang J" first="Jing" last="Wang">Jing Wang</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany; State Key Lab of Cognitive Neuroscience and Learning, Beijing Normal University, P. R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany; State Key Lab of Cognitive Neuroscience and Learning, Beijing Normal University</wicri:regionArea><wicri:noRegion>Beijing Normal University</wicri:noRegion></affiliation></author><author><name sortKey="Hirschmann, Jan" sort="Hirschmann, Jan" uniqKey="Hirschmann J" first="Jan" last="Hirschmann">Jan Hirschmann</name></author><author><name sortKey="Elben, Saskia" sort="Elben, Saskia" uniqKey="Elben S" first="Saskia" last="Elben">Saskia Elben</name></author><author><name sortKey="Hartmann, Christian J" sort="Hartmann, Christian J" uniqKey="Hartmann C" first="Christian J" last="Hartmann">Christian J. Hartmann</name></author><author><name sortKey="Vesper, Jan" sort="Vesper, Jan" uniqKey="Vesper J" first="Jan" last="Vesper">Jan Vesper</name></author><author><name sortKey="Wojtecki, Lars" sort="Wojtecki, Lars" uniqKey="Wojtecki L" first="Lars" last="Wojtecki">Lars Wojtecki</name></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Brain Mapping</term><term>Brain Waves (physiology)</term><term>Deep Brain Stimulation</term><term>Electrodes, Implanted</term><term>Electroencephalography</term><term>Female</term><term>Humans</term><term>Intraoperative Period</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Severity of Illness Index</term><term>Spectrum Analysis</term><term>Subthalamic Nucleus (physiology)</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Brain Waves</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Brain Mapping</term><term>Deep Brain Stimulation</term><term>Electrodes, Implanted</term><term>Electroencephalography</term><term>Female</term><term>Humans</term><term>Intraoperative Period</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term><term>Spectrum Analysis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The pathophysiology of Parkinson's disease (PD) has been related to excessive beta band oscillations in the basal ganglia. Recent recordings from the subthalamic nucleus of PD patients showed that beta oscillations show strong cross-frequency coupling with high-frequency oscillations (>200 Hz). However, little is known about the characteristics and functional properties of these oscillations. We studied the spatial distribution of high-frequency oscillations and their relation to PD motor symptoms. We included 10 PD patients in medication OFF who underwent implantation of deep brain stimulation (DBS) electrodes. Intraoperative five-channel microelectrode recordings were performed at 9 to 10 recording sites within the subthalamic nucleus and its immediate surroundings. We found a focal spatial distribution of high-frequency oscillations with highest power 2 mm below the dorsolateral border of the subthalamic nucleus. Within the subthalamic nucleus, power peaked slightly anterior to the DBS target site. In addition, contralateral akinesia/rigidity scores were negatively correlated with high-frequency oscillation power. Our results demonstrate a focal origin of high-frequency oscillations within the subthalamic nucleus and provide further evidence for their functional association with motor state.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Elben, Saskia" sort="Elben, Saskia" uniqKey="Elben S" first="Saskia" last="Elben">Saskia Elben</name><name sortKey="Hartmann, Christian J" sort="Hartmann, Christian J" uniqKey="Hartmann C" first="Christian J" last="Hartmann">Christian J. Hartmann</name><name sortKey="Hirschmann, Jan" sort="Hirschmann, Jan" uniqKey="Hirschmann J" first="Jan" last="Hirschmann">Jan Hirschmann</name><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><name sortKey="Vesper, Jan" sort="Vesper, Jan" uniqKey="Vesper J" first="Jan" last="Vesper">Jan Vesper</name><name sortKey="Wojtecki, Lars" sort="Wojtecki, Lars" uniqKey="Wojtecki L" first="Lars" last="Wojtecki">Lars Wojtecki</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Wang, Jing" sort="Wang, Jing" uniqKey="Wang J" first="Jing" last="Wang">Jing Wang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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